Cognitive Movement Disorders, Gut Dysbiosis and Skin Diseases

Bridging the Gap between Gut Microbial Dysbiosis and Cardiovascular Diseases

The human gut is heavily colonized by a community of microbiota, primarily bacteria, that exists in a symbiotic relationship with the host and plays a critical role in maintaining host homeostasis. The consumption of a high-fat (HF) diet has been shown to induce gut dysbiosis and reduce intestinal integrity. Recent studies have revealed that dysbiosis contributes to the progression of cardiovas...

Gut Microbiota and Neuropsychiatric Disorders

Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication

Emerging evidence indicates that disruption of the gut microbial community (dysbiosis) impairs mental health. Germ-free mice and antibiotic-induced gut dysbiosis are two approaches to establish causality in gut microbiota-brain relationships. However, both models have limitations, as germ-free mice display alterations in blood-brain barrier and brain ultrastructure and antibiotics may act direc...

Normal Development of Gut Microbiota and Dysbiosis

Antibiotics are often prescribed inappropriately to infants and young children, with potentially adverse effects on the developing gut microbiota and related metabolic processes. We review evidence from 17 epidemiologic studies suggesting that antibiotic exposure during critical periods of early development may influence weight gain and the development of obesity. Complementary research in both...

Cognitive dysfunction and dementia in movement disorders

Alzheimer’s disease (AD) and Parkinson’s disease (PD) represent the most common neurodegenerative disorders, and while AD is the most prevalent cause of dementia, PD, the commonest bradykinetic movement disorder, has a cumulative prevalence of dementia of 75-90% (PD dementia – PDD) particularly in patients with a disease duration of 10 years or longer. At the opposite end of the spectrum of mov...